Relationship between patients’ pre-operative anxiety level and administration of anxiolytic premedication
Pre-operative anxiety and use of anxiolytic medication
DOI:
https://doi.org/10.26550/2209-1092.1391Keywords:
assessing acute pre-operative anxiety, use of anxiolytic premedication, role of perioperative nursingAbstract
Objective: To evaluate the relationship between the patient’s reported level of pre-operative anxiety, the anaesthesiologist’s assessment of the patients’ anxiety level and the administration of anxiolytic premedication in the immediate pre-operative period.
Methods: Patients' pre-operative anxiety level was self-assessed using a simple visual analog scale (0 = no anxiety to 10 = severe anxiety) in the pre-operative holding area. The anaesthesiologist independently visually assessed the patient’s level of anxiety on a similar 0 to 10 anxiety rating scale at the time of their pre-operative interview. Immediately after this, the anaesthesiologist decided whether to administer an anxiolytic medication prior to the patient entering the operating room.
Results: Based on the anxiety scores reported by patients on the numeric analog scale, 58% (n=171) reported no-to-low levels of anxiety (scores ≤3) and 42% (n=122) reported moderate-to-high levels of anxiety (scores ≥4). According to the observational assessment by the anaesthesiologists, 70% of the patients were assigned an anxiety score ≤3 and 30% were assigned an anxiety score ≥4. Overall, 188 out of the 293 patients (64%) received a parenteral anxiolytic premedication. However, only 50% (61/122) of the patients reporting moderate-to-high levels of anxiety received an anxiolytic medication prior to entering the operating room. Surprisingly, 74% (127/171) of the patients reporting little or no anxiety were administered an anxiolytic drug. Interestingly, there was no significant difference in the average anxiety scores of patients who did or did not receive anxiolytic premedication (3.6±2.6 vs. 3.0±2.2, p= 0.11).
Conclusions: These data suggest there is poor correlation between the patient’s reported level of pre-operative anxiety and the administration of anxiolytic medication. A more targeted approach to administering anxiolytic premedication based on the patient’s self-reported anxiety level in the pre-operative holding area would lead to more rationale use of anxiolytic medication prior to the patient entering the operating room.
References
1. Rajput SK, Tiwari T, Chaudhary AK. Effect of preoperative multimedia based video information on perioperative anxiety and hemodynamic stability in patients undergoing surgery under spinal anesthesia. J Family Med Prim Care [Internet]. 2021[cited 2025 Aug 4];10(1):237-242. DOI: 10.4103/jfmpc.JFMPC_1544_20. PMID: 34017733
2. Eberhart L, Aust H, Schuster M, Sturm T, Gehling M, Euteneuer F et al. Preoperative anxiety in adults: A cross-sectional study on specific fears and risk factors. BMC Psychiatry [Internet]. 2020[cited 2025 Aug 4];20(1):140. DOI: 10.1186/s12888-020-02552-w. PMID: 32228525. PMCID: PMC7106568
3. Abate SM, Chekol YA, Basu B. Global prevalence and determinants of preoperative anxiety among surgical patients: a systematic review and meta-analysis [Internet]. Int J Surg Open. 2020[cited 2025 Aug 4];25:6-16. DOI: 10.1016/j.ijso.2020.05.010
4. Erkılıç E, Kesimci E, Soykut C, Doğer C, Gümüş T, Kanbak O. Factors associated with preoperative anxiety levels of Turkish surgical patients from a single center in Ankara [Internet]. Patient Prefer Adherence. 2017[cited 2025 Aug 4];11:291–6. DOI: 10.2147/PPA.S122953
5. Goyal P, Prisha, Chacko JS, Goyal A, Gupta S, Kathuria S. Assessment of perioperative anxiety levels at three time-points during hospital stay in patients undergoing elective surgery [Internet]. Perioper Med (Lond). 2025[cited 2025 Aug 4];14(1):27. DOI: 10.1186/s13741-025-00504-0. PMID: 40075428
6. Maranets I, Kain ZN. Preoperative anxiety and intraoperative anesthetic requirements [Internet]. Anesth Analg. 1999[cited 2025 Aug 4];89(6):1346–51. DOI: 10.1097/00000539-199912000-00003
7. van den Bosch JE, Moons KG, Bonsel GJ, Kalkman CJ. Does measurement of preoperative anxiety have added value for predicting postoperative nausea and vomiting? [Internet]. Anesth Analg. 2005[cited 2025 Aug 4];100(5):1525–32. DOI: 10.1213/01.ANE.0000149325.20542.D4
8. Hernández-Palazón J, Fuentes-García D, Falcón-Araña L, Roca-Calvo MJ, Burguillos-López S, Doménech-Asensi P et al. Assessment of preoperative anxiety in cardiac surgery patients lacking a history of anxiety: Contributing factors and postoperative morbidity [Internet]. J Cardiothorac Vasc Anesth. 2018[cited 2025 Aug 4];32(1):236-244. DOI: 10.1053/j.jvca.2017.04.044.
9. Shebl MA, Toraih E, Shebl M, Tolba AM, Ahmed P, Banga HS et al. Preoperative anxiety and its impact on surgical outcomes: A systematic review and meta-analysis [Internet]. J Clin Transl Sci. 2025[cited 2025 Aug 4];9(1):e33. DOI: 10.1017/cts.2025.6
10. Hicks JA, Jenkins JG. The measurement of preoperative anxiety [Internet]. J R Soc Med. 1988[cited 2025 Aug 4];81(9):517–9. DOI: 10.1177/014107688808100907
11. Shafer A, White PF, Urquhart ML, Doze VA. Outpatient premedication: use of midazolam and opioid analgesics [Internet]. Anesthesiology. 1989[cited 2025 Aug 4];71(4):495–501. DOI: 10.1097/00000542-198910000-00006
12. White PF, Elvir Lazo OL. Rationale for assessing preoperative anxiety as part of the preoperative evaluation process [Internet]. J Clin Anesth. 2025[cited 2025 Aug 4];100:111656. DOI: 10.1016/j.jclinane.2024.111656
13. Kindler CH, Harms C, Amsler F, Ihde-Scholl T, Scheidegger D. The visual analog scale allows effective measurement of preoperative anxiety and detection of patients' anesthetic concerns [Internet]. Anesth Analg. 2000[cited 2025 Aug 4];90(3):706–12. DOI: 10.1097/00000539-200003000-00036. PMID: 10702461
14. Cao X, Yumul R, Elvir Lazo OL, Friedman J, Durra O, Zhang X et al. A novel visual facial anxiety scale for assessing preoperative anxiety [Internet]. PLoS One. 2017[cited 2025 Aug 4];12(2):e0171233. DOI: 10.1371/journal.pone.0171233
15. Yumul R, Elvir-Lazo OL, White PF, Zhang X, IsHak W, Chernobylsky D et al. Assessing preoperative anxiety: Comparison of three simple anxiety scales [Internet]. J Surg Res. 2024[cited 2025 Aug 4];7(3):386–94. DOI: 10.26502/jsr.10020385
16. van Vlymen JM, Sá Rêgo MM, White PF. Benzodiazepine premedication: Can it improve outcome in patients undergoing breast biopsy? [Internet]. Anesthesiology. 1999[cited 2025 Aug 4];90(3):740–7. DOI: 10.1097/00000542-199903000-00016
17. Apfelbaum JL, Connis RT, Nickinovich DG, Pasternak LR, Arens JF, Caplan RA et al. Practice advisory for preanesthesia evaluation: An updated report [Internet]. Anesthesiology. 2012[cited 2025 Aug 4];116(3):522–38. DOI: 10.1097/ALN.0b013e31823c1067
18. Mahanna-Gabrielli E, Schenning KJ, Deiner SG, Whittington RA. Pro-con debate: Judicious benzodiazepine administration for preoperative anxiolysis in older patients [Internet]. Anesth Analg. 2023[cited 2025 Aug 4];137(2):280–8. DOI: 10.1213/ANE.0000000000006337
19. Cozowicz C, Zhong H, Illescas A, Athanassoglou V, Poeran J, Reichel JF et al. The perioperative use of benzodiazepines for major orthopedic surgery in the United States [Internet]. Anesth Analg. 2022[cited 2025 Aug 4];134(3):486–95. DOI: 10.1213/ANE.0000000000005854
20. Park CM, Inouye SK, Marcantonio ER, Metzger E, Bateman BT, Lie JJ et al. Perioperative gabapentin use and in-hospital adverse clinical events among older adults after major surgery [Internet]. JAMA Intern Med. 2022[cited 2025 Aug 4];182(11):1117–27. DOI: 10.1001/jamainternmed.2022.3680
21. Bongiovanni T, Anderson TS, Marcum ZA. Perioperative gabapentin use in older adults: Revisiting multimodal pain management [Internet]. JAMA Intern Med. 2022[cited 2025 Aug 4];182(11):1127–8. DOI: 10.1001/jamainternmed.2022.3757
22. Fekrat F, Sahin A, Yazici KM, Aypar U. Anaesthetists’ and surgeons’ estimation of preoperative anxiety by patients submitted for elective surgery in a university hospital [Internet]. Eur J Anaesthesiol. 2006[cited 2025 Aug 4];23(3):227–33. DOI: 10.1017/S0265021505002061
23. Laufenberg-Feldmann R, Kappis B, Schuster M, Ferner M. Relevance of preoperative anxiety for postoperative outcome in urological surgery patients: A prospective observational study [Internet]. Schmerz. 2016[cited 2025 Aug 4];30(2):166–73. DOI: 10.1007/s00482-015-0023-3. PMID: 26242358
24. Domar AD, Everett LL, Keller MG. Preoperative anxiety: Is it a predictable entity? Anesth Analg [Internet]. 1989[cited 2025 Aug 4];69(6):763–7. DOI: 10.1213/00000539-198912000-00016
25. Carroll JK, Cullinan E, Clarke L, Davis NF. The role of anxiolytic premedication in reducing preoperative anxiety [Internet]. Br J Nurs. 2012[cited 2025 Aug 4];21(8):479–83. DOI: 10.12968/bjon.2012.21.8.47
26. Zemła AJ, Nowicka-Sauer K, Jarmoszewicz K, Wera K, Batkiewicz S, Pietrzykowska M. Measures of preoperative anxiety [Internet]. Anaesthesiol Intensive Ther. 2019[cited 2025 Aug 4];51(1):64–9. DOI: 10.5603/AIT.2019.0013
27. Ni K, Zhu J, Ma Z. Preoperative anxiety and postoperative adverse events: A narrative overview [Internet]. Anesthesiol Perioper Sci. 2023[cited 2025 Aug 4];1(3):23. DOI: 10.1007/s44254-023-00019-1
28. Williams JB, Alexander KP, Morin JF et al. Preoperative anxiety as a predictor of mortality and major morbidity in patients aged >70 years undergoing cardiac surgery [Internet]. Am J Cardiol. 2013[cited 2025 Aug 4];111(1):137–42. DOI: 10.1016/j.amjcard.2012.08.060
29. Kil HK, Kim WO, Chung WY, Kim GH, Seo H, Hong JY. Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia [Internet]. Br J Anaesth. 2012[cited 2025 Aug 4];108(1):119–25. DOI: 10.1093/bja/aer305
30. Ali A, Altun D, Oguz BH, Ilhan M, Demircan F, Koltka K. The effect of preoperative anxiety on postoperative analgesia and anesthesia recovery in patients undergoing laparoscopic cholecystectomy [Internet]. J Anesth. 2014[cited 2025 Aug 4];28(2):222–7. DOI: 10.1007/s00540-013-1712-7
31. Raichle KA, Osborne TL, Jensen MP, Ehde DM, Smith DG, Robinson LR. Preoperative state anxiety, acute postoperative pain, and analgesic use in persons undergoing lower limb amputation [Internet]. Clin J Pain. 2015[cited 2025 Aug 4];31(8):699–706. DOI: 10.1097/AJP.0000000000000150
32. Walker KJ, Smith AF. Premedication for anxiety in adult day surgery [Internet]. Cochrane Database Syst Rev. 2009[cited 2025 Aug 4];(4):CD002192. DOI: 10.1002/14651858.CD002192.pub2.
33. Moerman N, van Dam FSAM, Muller MJ, Oosting H. The Amsterdam preoperative Anxiety and information scale (APAIS) [Internet]. Anesth Analg. 1996[cited 2025 Aug 4];82(3):445–51. DOI: 10.1097/00000539-199603000-00002
34. Li XR, Zhang WH, Williams JP, Li T, Yuan JH, Du Y et al. A multicenter survey of perioperative anxiety in China: Pre- and postoperative associations [Internet]. J Psychosom Res. 2021[cited 2025 Aug 4];147:110528. DOI: 10.1016/j.jpsychores.2021.110528
35. Kim WS, Byeon GJ, Song BJ, Lee HJ. Availability of preoperative anxiety scale as a predictive factor for hemodynamic changes during induction of anesthesia [Internet]. Korean J Anesthesiol. 2010[cited 2025 Aug 4];58(4):328–33. DOI: 10.4097/kjae.2010.58.4.328
36. Caumo W, Schmidt AP, Schneider CN, Bergmann J, Iwamoto CW, Bandeira D et al. Risk factors for preoperative anxiety in adults [Internet]. Acta Anaesthesiol Scand. 2001[cited 2025 Aug 4];45(3):298–307. DOI: 10.1034/j.1399-6576.2001.045003298.x
37. Yu J, Zhang Y, Yu T, Mi W, Yao S, Wang Z et al. Preoperative anxiety in Chinese adult patients undergoing elective surgeries: A multicenter cross-sectional study [Internet]. World J Surg. 2022[cited 2025 Aug 4];46(12):2927–38. DOI: 10.1007/s00268-022-06720-9
38. Sigdel S. Perioperative anxiety: A short review[Internet]. Glob Anesth Perioper Med. 2015[cited 2025 Aug 4];1(4):107–8. DOI: 10.15761/GAPM.1000126
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